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Researchers at the University of California,[link widoczny dla zalogowanych], Santa Cruz, have developed a new strategy for finding novel antibiotic compounds, using a diagnostic panel of bacterial strains for screening chemical extracts from natural sources.
The researchers started with a training set of 72 commercially available antibiotics and tested them all against a panel of 15 bacterial strains,[link widoczny dla zalogowanych], including a broad range of clinically important pathogens. The commercial antibiotics were chosen to include multiple members of all of the main classes of antibiotics. Parallel screening of the antibiotics against all 15 strains was performed using robotic equipment at the UCSC Chemical Screening Center.



The new screening procedure,[link widoczny dla zalogowanych], called BioMAP (antibiotic mode of action profile),[link widoczny dla zalogowanych], promises to streamline the discovery of new antibiotics from natural sources by providing a low-cost,[link widoczny dla zalogowanych], high-throughput platform for identifying compounds with novel antibiotic properties.

"If you take a library of natural product extracts and screen them against a bacterial target,[link widoczny dla zalogowanych], you will find a lot of antibacterial compounds, but almost all of them will be known structures,[link widoczny dla zalogowanych]," said Roger Linington,[link widoczny dla zalogowanych], assistant professor of chemistry and biochemistry at UC Santa Cruz. "BioMAP is a new way to look at antibiotic activity so that you're not wasting time and energy chasing things that turn out to be well-studied compounds of little therapeutic value."
Public health officials warn of a looming antibiotic crisis due to the steady increase in antibiotic resistance and a dramatic decline in the development of new antibiotics. Most currently available antibiotics are derived from natural compounds produced by microorganisms such as bacteria and fungi. New antibiotics developed by drug companies are often synthetically tailored variations of existing classes of antibiotics. To combat the problem of antibiotic resistance, however,[link widoczny dla zalogowanych], researchers desperately want to find antibiotics with completely novel structures and modes of action.

The tests yielded a characteristic pattern of activity,[link widoczny dla zalogowanych], or BioMAP profile,[link widoczny dla zalogowanych], for each antibiotic, and antibiotics within the same class had similar profiles. Analysis using hierarchical clustering methods showed that the BioMAP profiles are highly diagnostic for the known structural classes of antibiotics. The researchers then showed that the procedure could be used to classify compounds present in natural product extracts and identify novel antibiotics.
Linington's lab focuses on marine natural products--mostly microorganisms isolated from marine sediments--as a source of lead compounds for drug discovery. The BioMAP project was led by Weng Ruh Wong,[link widoczny dla zalogowanych], who joined the lab as a postdoctoral fellow in the QB3-Malaysia Program. Wong is first author of a paper presenting the BioMAP screening procedure published in the November 21 issue of Chemistry & Biology.
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Anbar province has been the scene of fierce clashes after Iraqi police dismantled an anti-government protest site outside Ramadi, the provincial capital, in late December.
In Baghdad, a car bomb went off at a busy intersection of Adan in Kadhmiyah district in the northern part of the Iraqi capital, killing four people and wounding 14 others, the source said.

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assault tactics; prominent army maneuvers evaluation system,[link widoczny dla zalogowanych], focusing on testing of command and control, remote maneuver, firepower, the overall protection and comprehensive support 5 kinds of ability, especially the inspection forces in the complex electromagnetic environment of the combat action Nexuiz.
"across the -2009? Taonan" real soldiers of the examination exercise,[link widoczny dla zalogowanych], the headquarters of the organization is a guide, the relevant universities and scientific research units to participate in, take the "headquarters organizations, universities participate in the military coordination, base security,[link widoczny dla zalogowanych]," way of trans-regional base training exercise. Exercises directed by director assessment group,[link widoczny dla zalogowanych], information acquisition conditioning group, that group, technical support and service support group. A division of the Lanzhou military region in.
highlight the walkthrough of complex electromagnetic under the environment of the operation, make full use of new electronic warfare weapon equipment system, to carry out a wide range of electronic reconnaissance and anti - reconnaissance,[link widoczny dla zalogowanych], jamming and anti-jamming, deception and deceives, destroy and destroy action game, electronic attack and protection training will run through the whole process of exercise;
"across the -2009? Taonan" real soldiers of the examination exercise full live by live. "Across -200>
"across the -2009? Taonan" exercise, it will be done in the headquarters, command, and Strategy:
prominent chief organs of the collaborative drill, inspection planning and coordination ability in the complex electromagnetic environment, complex commanders at all levels of complex climatic conditions, unfamiliar terrain under the command decision-making ability and the command organization;
xinhuanet.com news: August 11th morning 5 when, Lanzhou military area commands a pontoon bridge using 45 minutes, the erection of a more than 250 meters long bridge in the Yellow River, a ferry; six o'clock, composed of 700 wheeled vehicle motorized units,[link widoczny dla zalogowanych], from the bridge on the rumble; 11, two with a division of the Lanzhou military region anaphora and special warfare unit personnel aircraft, an airport to fly from the northwest launched an Airport Northeast; at the same time, the two column carrying armored equipment,[link widoczny dla zalogowanych], special equipment and engineering machinery will be fully equipped for. In this connection, a code for "across the -2009? Taonan" military exercises in full swing, "beyond -2009" series of real soldiers of the examination exercise officially kicked off.
highlight the air and ground fire precision attack training, focus on joint air-ground close coordination and the overall coordination, integrated joint operation system is under the condition of information confrontation,[link widoczny dla zalogowanych], precision strike,[link widoczny dla zalogowanych], key paralysis, stereo anti,[link widoczny dla zalogowanych], machine (umbrella) such as
during the 13 days of the exercise,[link widoczny dla zalogowanych], the division will cross 5 provinces (autonomous regions), continuous implementation, training, combat readiness level of combat readiness, conversion of early rapid maneuver, adjustment, implementation of combat deployment attack 5 training problem. During the exercise, the air force, army aviation force will be dispatched fighter,[link widoczny dla zalogowanych], attacker, transport aircraft, helicopter gunships in combat and air transportation and accurate fire assault, stereo Heli attack drill.
- base training is a new form of group training, aims to bring breakthrough of regional division, service limits and institutional constraints of the original "bottleneck", a comprehensive training to improve the combat capability of troops maneuvering and global.
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Shanxi Mount Wutai scenic area of Taiwan Huai temples over the emergence of multicoloured auspicious clouds, so there is a Chinese idiom "auspicious sign" or "Rui Cai auspicious clouds".

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mediators: hot springs,[link widoczny dla zalogowanych], hot springs street justice mediator Lin Zhongrong Joan Rivers community public security director Liu Meiying
should send your city is new resettlement housing, others just put into use, the owners get the key in the decoration. 3 building 2807 room owners Ms. Yan said, her husband was seriously ill, just do the operation in the provincial hospital, home to see a house is 2806 room air conditioners neighbors for. Neighbors said that the property management office director Lin agreed. Lin has been the property of the company laid off, the property management office now zhengmou says it has nothing to do with the property owners themselves, solved by two. Ms Wu said, her husband almost fainted.
new home air conditioners spaces
Ms. Yan: after getting the key, because his wife is sick, we haven't enough time to go to the new house decoration. His wife just got out of the hospital,[link widoczny dla zalogowanych], I went to the new premises have a look, found that air conditioners spaces bedroom is in room 2806, neighbors for. From the housing the drawing point of view,[link widoczny dla zalogowanych], this is the two air conditioners in my family. Now, air conditioners are neighbors for, after our air-conditioning outside the machine where? This is our right to use air conditioners, we want to get back.
Mr. Wu and his son: my door corridor I one family use, air conditioners in my door wall, close to my kitchen,[link widoczny dla zalogowanych], so we think it is their own. Later,[link widoczny dla zalogowanych], we asked the then director of the property management office to Lin, he told us, there is an air conditioners is ours, so the page
by the Fuzhou evening news and Gulou District Justice Bureau jointly "evening mediation room", is a public service platform. Columns organized a warm-hearted, effective mediation team, try to help people solve the contradiction between husband and wife, divorce, alimony,[link widoczny dla zalogowanych], child education problems. If you or your friend needs to mediate interaction, please join QQ group (group 297295476), or call the reporter Liu Dongbin on the phone, or to Qingyuan Fu Yu Lu Hong Jin 1 evening mediation room consultation window on-site consultation, but also through the Sina micro-blog or Tencent micro-blog @ Fuzhou evening news. If you are happy when the public adjuster, please contact us. Welcome to login "evening news online · East Street" web site (www.fzen.com.cn),[link widoczny dla zalogowanych], on each of the issues are discussed,[link widoczny dla zalogowanych], for the trouble the weapon.
moderator invited
anchor: reporter, two levels of marriage and family counseling Liu Dongbin
suffered a "dog in the manger&quot,[link widoczny dla zalogowanych];
mediation object: Hot Spring Street de Gui Lu, Gulou District Yifa de your city 3 building 2807 room owners Ms. Yan (60 years old),[link widoczny dla zalogowanych], 2806 room owners Mr. Wu and his son,[link widoczny dla zalogowanych], should de expensive city property manager Zheng
by the Fuzhou evening news of people's mediation committees and Spa judicial joint mediation, room 2806,[link widoczny dla zalogowanych], Mr. Wu and his son have agreed to move air-conditioning outside the machine, but the transfer fees and charges, the laying of pipelines ceiling tuition has become the ultimate focus of mediation, the two owners are pointing to the property company.
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yesterday, love people and our reporter, condolences to the families. Among them, 15 households living in the family household will receive 800 yuan in cash and a bag of rice, a barrel of oil and a box of instant noodles, 17 other families will get rice and oil.

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February 1st,[link widoczny dla zalogowanych], Mount Holyoke County Agricultural Committee held the old cadres spring tea party,[link widoczny dla zalogowanych], from the county agricultural system more than 50 retired cadres and Party members of the team have a joyous gathering COA,[link widoczny dla zalogowanych], friendship,[link widoczny dla zalogowanych], talk about feelings.
the tea party,[link widoczny dla zalogowanych], the county government of member of leading Party group,[link widoczny dla zalogowanych], farming appoint director Zhang Fangying on behalf of the Party group to express our heartfelt thanks to all the old leaders,[link widoczny dla zalogowanych], old comrades for many years on the commission work of the concern and support, sent to the blessing of the Chinese New Year in 2013 to the eve of the Spring Festival,[link widoczny dla zalogowanych], and a comprehensive report on the work in 2012 and 2013 work plan. The eighteen report, the central document No.1 and the central,[link widoczny dla zalogowanych], provincial rural work conference spirit, you old cadres,[link widoczny dla zalogowanych], each airs his own views. Speak one's mind freely, agreed that the commission a years work measures are effective, gratifying results, the effect is remarkable; the eighteen report and the central document No.1, the creation of the world, as in the past attention to inspire people,[link widoczny dla zalogowanych], said it will support the agricultural work,[link widoczny dla zalogowanych], the whole Party laughter one, filled with a happy atmosphere, the 90 year old retired veteran Li Fuhou old man Improvisation for everybody sings a Peking Opera, is the atmosphere to a climax. (red)
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May 7th, comrade Zhu Baoping led "to rule against" special action leading group members, deep into the seven low-cost rental, Chengguan town Huoqiu Sunshine Holiday City, lying splendid city, Yang Guan Zhen Tao Yuan houses site conducted a special inspection.